Reese Witherspoon, Seth Rogen, Hugh Laurie, Will Arnett, Kiefer Sutherland and John Krasinski all voice characters for this animated 3-D adaptation of the popular comic-book series. When a meteorite from outer space hits a young woman (Witherspoon) and turns her into a giant monster, she is taken to a secret government compound where she meets others like her who have been rounded up over the years. Under the guidance of General W.R. Monger, the motley crew of Monsters is ultimately called in to combat the human-hating aliens before they can destroy the world.